In addition to having a properly fit bike, having proper apparel is also important. Having a properly fitted helmet is very important. Wearing cycling shorts also helps because of the padding helps pad the pelvis area and also wicks away the sweat. Having gloves helps pad with the vibration of the bike to prevent some of the numbness and tingling you can have in your hands also.
Something else to consider with cycling is proper hydration. Since you're going to be riding your bike for a while, it is very important to hydrate before you ride, but then also to have water along with you when you ride. Most bikes you can get or are equipped with cages that you can hold water then too and take that with you on your bike ride.
Most cycling shirts have pockets in the back so you can load up your pockets with fruits and protein bars. If you are going on a long ride, it is important to have some extra food along with you to help fuel yourself as you ride.