Are there conditions that can cause early menopause?

In some patients, menopause can occur much earlier than expected. Even in the late 30's. Usually, we don't know why someone goes through premature menopause. Generally what we do when that occurs is we do do an evaluation to look for rheumatic diseases, autoimmune diseases, because those can be associated with premature menopause. Menopause before the age of 40 is considered abnormal and requires a workup.